Generic Zyban Chemical Name: BUPROPION Common uses This medicine is a smoking cessation aid used to help you stop smoking.
Generic zyban bupropion Manufacturer Pfizer Limited (In: Pfizer) United Kingdom
Phase 2 clinical trial data
FDA approved Zyban in 2000 for the treatment of depression. In 2009 the U.S. Food and Drug Administration extended the patent rights on Zyban (Zyban XR).
Data are reported from the phase 2 clinical trial. trial enrolled 5,521 patients who were first randomised to be treated with Zyban for 28 days and then followed 18 months later (Phase 3 Phase 3). The main outcome measure was change in the Hamilton Depression Rating Scale (HDRS), a 10-item for the assessment of depression:
HAM-D (HAM-D-13-Q)
1=Not at all, 2=Somewhat, 3=Very much, 4=Very 5=Extremely.
HAM-D-13-Q = (H+Q/12)*(H+Q+1)+(H+Q+2)+(H+Q+3)+(H+Q+4).
=HDRS score (HAM-D score) of greater than 28 days from randomisation for at least one symptom.
HAM-D-13-Q was administered at the time of randomisation and monthly thereafter at 4-months follow-up up until the end of study.
The primary endpoint was change from baseline in HDRS score at 28 days. Secondary endpoints included change in depression as assessed by the Montgomery Asberg Depression Rating Scale as well change in social functioning.
In this review we identified data from two ongoing phase 2 clinical trials. The findings did not meet high quality standard for publication. No data were included in the Cochrane database nor were any data from the clinical trial of ZYNGA (Zyban®). We therefore cannot be certain which trials were included. This paper evaluates the two phases of clinical trials zyban over the counter uk using the following generic for zyban criteria:
a randomised controlled trial or,
a non-randomised controlled trial with non-overlapping groups.
Data are presented at the lower end of range presented by a randomised controlled trial or at the very high end of range presented by a non-randomised controlled trial with overlapping groups. In this review we did not find any data from the trials (ZYNGA and VIBRIS) that met the inclusion zyban online uk criterion so are not included.
The overall quality score for this publication was 1 [Table 1]. The authors of one study (Larson et al) stated that no data were available and could not comment on the consistency of their studies that met quality criteria. It is not clear if all data for the trials were collected during study process of these two studies or if some data were collected prior to the study, especially in case of the trial reported herein: Larson et al. [23]. This is similar to the finding of.
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